Cytoplasmic Cyclin E and Phospho–Cyclin-Dependent Kinase 2 Are Biomarkers of Aggressive Breast Cancer

Cyclin E and its co-activator, phospho–cyclin-dependent kinase 2 (p-CDK2), regulate G(1) to S phase transition and their deregulation induces oncogenesis. Immunohistochemical assessments of these proteins in cancer have been reported but were based only on their nuclear expression. However, the onco...

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Bibliographische Detailangaben
Veröffentlicht in:Am J Pathol
Hauptverfasser: Karakas, Cansu, Biernacka, Anna, Bui, Tuyen, Sahin, Aysegul A., Yi, Min, Akli, Said, Schafer, Jolie, Alexander, Angela, Adjapong, Opoku, Hunt, Kelly K., Keyomarsi, Khandan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Investigative Pathology 2016
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Regular Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4929404/
https://ncbi.nlm.nih.gov/pubmed/27182644
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2016.02.024
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