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DNA Hypermethylation of CREB3L1 and Bcl-2 Associated with the Mitochondrial-Mediated Apoptosis via PI3K/Akt Pathway in Human BEAS-2B Cells Exposure to Silica Nanoparticles

The toxic effects of silica nanoparticles (SiNPs) are raising concerns due to its widely applications in biomedicine. However, current information about the epigenetic toxicity of SiNPs is insufficient. In this study, the epigenetic regulation of low-dose exposure to SiNPs was evaluated in human bro...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Zou, Yang, Li, Qiuling, Jiang, Lizhen, Guo, Caixia, Li, Yanbo, Yu, Yang, Li, Yang, Duan, Junchao, Sun, Zhiwei
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4928798/
https://ncbi.nlm.nih.gov/pubmed/27362941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158475
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