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DNA Hypermethylation of CREB3L1 and Bcl-2 Associated with the Mitochondrial-Mediated Apoptosis via PI3K/Akt Pathway in Human BEAS-2B Cells Exposure to Silica Nanoparticles

The toxic effects of silica nanoparticles (SiNPs) are raising concerns due to its widely applications in biomedicine. However, current information about the epigenetic toxicity of SiNPs is insufficient. In this study, the epigenetic regulation of low-dose exposure to SiNPs was evaluated in human bro...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Zou, Yang, Li, Qiuling, Jiang, Lizhen, Guo, Caixia, Li, Yanbo, Yu, Yang, Li, Yang, Duan, Junchao, Sun, Zhiwei
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4928798/
https://ncbi.nlm.nih.gov/pubmed/27362941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158475
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