CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma

Metastatic renal cell carcinoma (mRCC) is nearly incurable and accounts for most of the mortality associated with RCC. Von Hippel Lindau (VHL) is a tumour suppressor that is lost in the majority of clear cell RCC (ccRCC) cases. Its role in regulating hypoxia-inducible factors-1α (HIF-1α) and -2α (HI...

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Publicado no:Sci Rep
Main Authors: Schokrpur, Shiruyeh, Hu, Junhui, Moughon, Diana L., Liu, Peijun, Lin, Lucia C., Hermann, Kip, Mangul, Serghei, Guan, Wei, Pellegrini, Matteo, Xu, Hua, Wu, Lily
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4928183/
https://ncbi.nlm.nih.gov/pubmed/27358011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29032
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