CRISPR-Mediated VHL Knockout Generates an Improved Model for Metastatic Renal Cell Carcinoma

Metastatic renal cell carcinoma (mRCC) is nearly incurable and accounts for most of the mortality associated with RCC. Von Hippel Lindau (VHL) is a tumour suppressor that is lost in the majority of clear cell RCC (ccRCC) cases. Its role in regulating hypoxia-inducible factors-1α (HIF-1α) and -2α (HI...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Schokrpur, Shiruyeh, Hu, Junhui, Moughon, Diana L., Liu, Peijun, Lin, Lucia C., Hermann, Kip, Mangul, Serghei, Guan, Wei, Pellegrini, Matteo, Xu, Hua, Wu, Lily
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4928183/
https://ncbi.nlm.nih.gov/pubmed/27358011
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29032
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