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Adenosine diphosphate restricts the protein remodeling activity of the Hsp104 chaperone to Hsp70 assisted disaggregation

Hsp104 disaggregase provides thermotolerance in yeast by recovering proteins from aggregates in cooperation with the Hsp70 chaperone. Protein disaggregation involves polypeptide extraction from aggregates and its translocation through the central channel of the Hsp104 hexamer. This process relies on...

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Vydáno v:eLife
Hlavní autoři: Kłosowska, Agnieszka, Chamera, Tomasz, Liberek, Krzysztof
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications, Ltd 2016
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4927293/
https://ncbi.nlm.nih.gov/pubmed/27223323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.15159
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