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Adenosine diphosphate restricts the protein remodeling activity of the Hsp104 chaperone to Hsp70 assisted disaggregation

Hsp104 disaggregase provides thermotolerance in yeast by recovering proteins from aggregates in cooperation with the Hsp70 chaperone. Protein disaggregation involves polypeptide extraction from aggregates and its translocation through the central channel of the Hsp104 hexamer. This process relies on...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Kłosowska, Agnieszka, Chamera, Tomasz, Liberek, Krzysztof
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4927293/
https://ncbi.nlm.nih.gov/pubmed/27223323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.15159
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