Role of Mitochondrial DNA in Septic AKI via Toll-Like Receptor 9

Toll-like receptor 9 (TLR9) contributes to the development of polymicrobial septic AKI. However, the mechanisms that activate the TLR9 pathway and cause kidney injury during sepsis remain unknown. To determine the role of mitochondrial DNA (mtDNA) in TLR9-associated septic AKI, we established a ceca...

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Bibliographic Details
Published in:J Am Soc Nephrol
Main Authors: Tsuji, Naoko, Tsuji, Takayuki, Ohashi, Naro, Kato, Akihiko, Fujigaki, Yoshihide, Yasuda, Hideo
Format: Artigo
Language:Inglês
Published: American Society of Nephrology 2016
Subjects:
Basic Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4926971/
https://ncbi.nlm.nih.gov/pubmed/26574043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2015040376
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