Efficient production of multi-modified pigs for xenotransplantation by ‘combineering’, gene stacking and gene editing

Xenotransplantation from pigs could alleviate the shortage of human tissues and organs for transplantation. Means have been identified to overcome hyperacute rejection and acute vascular rejection mechanisms mounted by the recipient. The challenge is to combine multiple genetic modifications to enab...

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Published in:Sci Rep
Main Authors: Fischer, Konrad, Kraner-Scheiber, Simone, Petersen, Björn, Rieblinger, Beate, Buermann, Anna, Flisikowska, Tatiana, Flisikowski, Krzysztof, Christan, Susanne, Edlinger, Marlene, Baars, Wiebke, Kurome, Mayuko, Zakhartchenko, Valeri, Kessler, Barbara, Plotzki, Elena, Szczerbal, Izabela, Switonski, Marek, Denner, Joachim, Wolf, Eckhard, Schwinzer, Reinhard, Niemann, Heiner, Kind, Alexander, Schnieke, Angelika
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4926246/
https://ncbi.nlm.nih.gov/pubmed/27353424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29081
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