Inactivation and Inducible Oncogenic Mutation of p53 in Gene Targeted Pigs

Mutation of the tumor suppressor p53 plays a major role in human carcinogenesis. Here we describe gene-targeted porcine mesenchymal stem cells (MSCs) and live pigs carrying a latent TP53(R167H) mutant allele, orthologous to oncogenic human mutant TP53(R175H) and mouse Trp53(R172H), that can be activ...

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Autors principals: Leuchs, Simon, Saalfrank, Anja, Merkl, Claudia, Flisikowska, Tatiana, Edlinger, Marlene, Durkovic, Marina, Rezaei, Nousin, Kurome, Mayuko, Zakhartchenko, Valeri, Kessler, Barbara, Flisikowski, Krzysztof, Kind, Alexander, Wolf, Eckhard, Schnieke, Angelika
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3465291/
https://ncbi.nlm.nih.gov/pubmed/23071491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0043323
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