AXL receptor tyrosine kinase is required for T cell priming and antiviral immunity

The receptor tyrosine kinase (RTK) AXL is induced in response to type I interferons (IFNs) and limits their production through a negative feedback loop. Enhanced production of type I IFNs in Axl(-/-)dendritic cells (DCs) in vitro have led to speculation that inhibition of AXL would promote antiviral...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Schmid, Edward T, Pang, Iris K, Carrera Silva, Eugenio A, Bosurgi, Lidia, Miner, Jonathan J, Diamond, Michael S, Iwasaki, Akiko, Rothlin, Carla V
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924996/
https://ncbi.nlm.nih.gov/pubmed/27350258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.12414
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