Syndromic deafness mutations at Asn 14 differentially alter the open stability of Cx26 hemichannels

Connexin 26 (Cx26) is a transmembrane protein that forms hexameric hemichannels that can function when unopposed or dock to form intercellular gap junction channels. Aberrantly functioning unopposed hemichannels are a common feature of syndromic deafness associated with mutations in Cx26. In this st...

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Detalles Bibliográficos
Publicado en:J Gen Physiol
Autores principales: Sanchez, Helmuth A., Slavi, Nefeli, Srinivas, Miduturu, Verselis, Vytas K.
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2016
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924935/
https://ncbi.nlm.nih.gov/pubmed/27353444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201611585
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