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Altered Inhibition of Cx26 Hemichannels by pH and Zn(2+) in the A40V Mutation Associated with Keratitis-Ichthyosis-Deafness Syndrome

Excessive opening of undocked Cx26 hemichannels in the plasma membrane is associated with disease pathogenesis in keratitis-ichthyosis-deafness (KID) syndrome. Thus far, excessive opening of KID mutant hemichannels has been attributed, almost solely, to aberrant inhibition by extracellular Ca(2+). T...

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Main Authors: Sanchez, Helmuth A., Bienkowski, Rick, Slavi, Nefeli, Srinivas, Miduturu, Verselis, Vytas K.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2014
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4118113/
https://ncbi.nlm.nih.gov/pubmed/24939841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.578757
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