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Syndromic deafness mutations at Asn 14 differentially alter the open stability of Cx26 hemichannels

Connexin 26 (Cx26) is a transmembrane protein that forms hexameric hemichannels that can function when unopposed or dock to form intercellular gap junction channels. Aberrantly functioning unopposed hemichannels are a common feature of syndromic deafness associated with mutations in Cx26. In this st...

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Библиографические подробности
Опубликовано в: :J Gen Physiol
Главные авторы: Sanchez, Helmuth A., Slavi, Nefeli, Srinivas, Miduturu, Verselis, Vytas K.
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 2016
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924935/
https://ncbi.nlm.nih.gov/pubmed/27353444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201611585
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