Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer

Werner syndrome protein (WRN) is a RecQ helicase that participates in DNA repair, genome stability and cellular senescence. The five human RecQ helicases, RECQL1, Bloom, WRN, RECQL4 and RECQL5 play critical roles in DNA repair and cell survival after treatment with the anticancer drug camptothecin (...

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Foilsithe in:Oncotarget
Main Authors: Shamanna, Raghavendra A., Lu, Huiming, Croteau, Deborah L., Arora, Arvind, Agarwal, Devika, Ball, Graham, Aleskandarany, Mohammed A., Ellis, Ian O., Pommier, Yves, Madhusudan, Srinivasan, Bohr, Vilhelm A.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Impact Journals LLC 2016
Ábhair:
Priority Research Paper
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924640/
https://ncbi.nlm.nih.gov/pubmed/26959889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7906
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