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Beyond small molecule SAR – using the dopamine D3 receptor crystal structure to guide drug design

The dopamine D3 receptor is a target of pharmacotherapeutic interest in a variety of neurological disorders including schizophrenia, restless leg syndrome, and drug addiction. The high protein sequence homology between the D3 and D2 receptors has posed a challenge to developing D3 receptor-selective...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Adv Pharmacol
Päätekijät: Keck, Thomas M., Burzynski, Caitlin, Shi, Lei, Newman, Amy Hauck
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924533/
https://ncbi.nlm.nih.gov/pubmed/24484980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/B978-0-12-420118-7.00007-X
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