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Beyond small molecule SAR – using the dopamine D3 receptor crystal structure to guide drug design

The dopamine D3 receptor is a target of pharmacotherapeutic interest in a variety of neurological disorders including schizophrenia, restless leg syndrome, and drug addiction. The high protein sequence homology between the D3 and D2 receptors has posed a challenge to developing D3 receptor-selective...

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Bibliographische Detailangaben
Veröffentlicht in:Adv Pharmacol
Hauptverfasser: Keck, Thomas M., Burzynski, Caitlin, Shi, Lei, Newman, Amy Hauck
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924533/
https://ncbi.nlm.nih.gov/pubmed/24484980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/B978-0-12-420118-7.00007-X
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