Rebamipide prevents peripheral arthritis and intestinal inflammation by reciprocally regulating Th17/Treg cell imbalance in mice with curdlan-induced spondyloarthritis

BACKGROUND: Spondyloarthritis (SpA) usually manifests as arthritis of the axial and peripheral joints but can also result in extra-articular manifestations such as inflammatory bowel disease. Proinflammatory cytokine interleukin-17 (IL-17) plays a crucial role in the pathogenesis of SpA. Rebamipide...

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Udgivet i:J Transl Med
Main Authors: Min, Hong-Ki, Kim, Jae-Kyung, Lee, Seon-Yeong, Kim, Eun-Kyung, Lee, Seung Hoon, Lee, Jennifer, Kwok, Seung-Ki, Cho, Mi-La, Park, Sung-Hwan
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924325/
https://ncbi.nlm.nih.gov/pubmed/27350608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0942-5
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