PTEN ameliorates autoimmune arthritis through down-regulating STAT3 activation with reciprocal balance of Th17 and Tregs

PTEN is a tyrosine phosphatase with significant function in inhibiting STAT3 activation. Recently, inactivation of STAT3 has been demonstrated as a therapeutic candidate for autoimmune arthritis. The expression of PTEN controlled by p53 regulates autoimmune arthritis through modulating the balance b...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Lee, Seung Hoon, Park, Jin-Sil, Byun, Jae-Kyung, Jhun, JooYeon, Jung, KyungAh, Seo, Hyeon-Beom, Moon, Young-Mee, Kim, Ho-Youn, Park, Sung-Hwan, Cho, Mi-La
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5052580/
https://ncbi.nlm.nih.gov/pubmed/27708408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep34617
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