GRIM19 ameliorates acute graft-versus-host disease (GVHD) by modulating Th17 and Treg cell balance through down-regulation of STAT3 and NF-AT activation

BACKGROUND: T helper (Th) 17 cells are a subset of T helper cells that express interleukin (IL)-17 and initiate the inflammatory response in autoimmune diseases. Regulatory T cells (Tregs) are a subpopulation of T cells that produce forkhead box P3 (FOXP3) and inhibit the immune response. Graft vers...

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Detalhes bibliográficos
Publicado no:J Transl Med
Main Authors: Park, Min-Jung, Lee, Seung Hoon, Lee, Sung-Hee, Kim, Eun-Kyung, Lee, Eun Jung, Moon, Young-Mee, La Cho, Mi-
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4938933/
https://ncbi.nlm.nih.gov/pubmed/27391226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-016-0963-0
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