Metformin Ameliorates Inflammatory Bowel Disease by Suppression of the STAT3 Signaling Pathway and Regulation of the between Th17/Treg Balance

OBJECTIVE: Metformin is used to treat type 2 diabetes. We sought to determine whether metformin reduces inflammation, by regulating p-signal transducer and activator of transcription 3 (STAT3) expression and T-helper 17 (Th17) cell proliferation, in a mouse model of inflammatory bowel disease (IBD)....

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Publicado en:PLoS One
Autores principales: Lee, Seon-Yeong, Lee, Seung Hoon, Yang, Eun-Ji, Kim, Eun-Kyung, Kim, Jae-Kyung, Shin, Dong-Yun, Cho, Mi-La
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4567351/
https://ncbi.nlm.nih.gov/pubmed/26360050
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0135858
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