Efficient elimination of pancreatic cancer stem cells by hedgehog/GLI inhibitor GANT61 in combination with mTOR inhibition

BACKGROUND: Pancreatic cancer is one of the most lethal malignancies. The innovative treatments are required and now the cancer stem cells (CSCs) are expected to be an effective target for novel therapies. Therefore we investigated the significance of hedgehog (Hh) signaling in the maintenance of CS...

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Détails bibliographiques
Publié dans:Mol Cancer
Auteurs principaux: Miyazaki, Yumi, Matsubara, Shyuichirou, Ding, Qiang, Tsukasa, Koichiro, Yoshimitsu, Makoto, Kosai, Ken-ichiro, Takao, Sonshin
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2016
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4924257/
https://ncbi.nlm.nih.gov/pubmed/27349387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-016-0534-2
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