GLI inhibitor GANT-61 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting Shh/AKT-mTOR axis

Rhabdomyosarcoma (RMS) typically arises from skeletal muscle. Currently, RMS in patients with recurrent and metastatic disease have no successful treatment. The molecular pathogenesis of RMS varies based on cancer sub-types. Some embryonal RMS but not other sub-types are driven by sonic hedgehog (Sh...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Srivastava, Ritesh K., Kaylani, Samer Zaid, Edrees, Nayf, Li, Changzhao, Talwelkar, Sarang S., Xu, Jianmin, Palle, Komaraiah, Pressey, Joseph G., Athar, Mohammad
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322980/
https://ncbi.nlm.nih.gov/pubmed/25432075
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