GLI inhibitor GANT-61 diminishes embryonal and alveolar rhabdomyosarcoma growth by inhibiting Shh/AKT-mTOR axis

Rhabdomyosarcoma (RMS) typically arises from skeletal muscle. Currently, RMS in patients with recurrent and metastatic disease have no successful treatment. The molecular pathogenesis of RMS varies based on cancer sub-types. Some embryonal RMS but not other sub-types are driven by sonic hedgehog (Sh...

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Библиографические подробности
Опубликовано в: :Oncotarget
Главные авторы: Srivastava, Ritesh K., Kaylani, Samer Zaid, Edrees, Nayf, Li, Changzhao, Talwelkar, Sarang S., Xu, Jianmin, Palle, Komaraiah, Pressey, Joseph G., Athar, Mohammad
Формат: Artigo
Язык:Inglês
Опубликовано: Impact Journals LLC 2014
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4322980/
https://ncbi.nlm.nih.gov/pubmed/25432075
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