GANT61 Reduces Hedgehog Molecule (GLI1) Expression and Promotes Apoptosis in Metastatic Oral Squamous Cell Carcinoma Cells

Due to its importance in the pathogenesis of oral squamous cell carcinoma (OSCC), the Hedgehog (HH) pathway is considered a potential therapeutic target. We investigated the effects of GANT61, a GLI inhibitor, on HH gene expression, as well as on metastatic OSCC cell proliferation and death. Followi...

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Опубликовано в: :Int J Mol Sci
Главные авторы: Bacelar Sacramento de Araújo, Taís, de Oliveira Siquara da Rocha, Leonardo, Torres Andion Vidal, Manuela, Cerqueira Coelho, Paulo Lucas, Galvão dos Reis, Mitermayer, Solano de Freitas Souza, Bruno, Botelho Pereira Soares, Milena, Almeida Pereira, Thiago, Della Coletta, Ricardo, Pereira Bezerra, Daniel, Borges Dias, Rosane, Araújo Gurgel Rocha, Clarissa
Формат: Artigo
Язык:Inglês
Опубликовано: MDPI 2020
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC7503713/
https://ncbi.nlm.nih.gov/pubmed/32846867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21176076
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