GD2-specific CAR T Cells Undergo Potent Activation and Deletion Following Antigen Encounter but can be Protected From Activation-induced Cell Death by PD-1 Blockade

Chimeric antigen receptor (CAR) T cells have shown great promise in the treatment of hematologic malignancies but more variable results in the treatment of solid tumors and the persistence and expansion of CAR T cells within patients has been identified as a key correlate of antitumor efficacy. Lack...

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Foilsithe in:Mol Ther
Main Authors: Gargett, Tessa, Yu, Wenbo, Dotti, Gianpietro, Yvon, Eric S, Christo, Susan N, Hayball, John D, Lewis, Ian D, Brenner, Malcolm K, Brown, Michael P
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2016
Ábhair:
Original Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4923328/
https://ncbi.nlm.nih.gov/pubmed/27019998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.63
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