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Immunotherapy of metastatic melanoma using genetically engineered GD2-specific T cells
PURPOSE: Genetic engineering of human T lymphocytes to express tumor-directed chimeric antigen receptors (CAR) can produce anti-tumor effector cells that bypass tumor immune escape mechanisms that are due to abnormalities in protein-antigen processing and presentation. Moreover, these transgenic rec...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2745508/ https://ncbi.nlm.nih.gov/pubmed/19737958 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-3163 |
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