Immunotherapy of metastatic melanoma using genetically engineered GD2-specific T cells

PURPOSE: Genetic engineering of human T lymphocytes to express tumor-directed chimeric antigen receptors (CAR) can produce anti-tumor effector cells that bypass tumor immune escape mechanisms that are due to abnormalities in protein-antigen processing and presentation. Moreover, these transgenic rec...

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Hlavní autoři: Yvon, Eric, Vecchio, Michele Del, Savoldo, Barbara, Hoyos, Valentina, Dutour, Aurélie, Anichini, Andrea, Dotti, Gianpietro, Brenner, Malcolm K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745508/
https://ncbi.nlm.nih.gov/pubmed/19737958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-3163
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