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Design and Development of Therapies using Chimeric Antigen Receptor-Expressing T cells

Investigators developed chimeric antigen receptors (CARs) for expression on T cells more than 25 years ago. When the CAR is derived from an antibody, the resultant cell should combine the desirable targeting features of an antibody (e.g. lack of requirement for major histocompatibility complex recog...

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Autors principals: Dotti, Gianpietro, Gottschalk, Stephen, Savoldo, Barbara, Brenner, Malcolm K
Format: Artigo
Idioma:Inglês
Publicat: 2014
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3874724/
https://ncbi.nlm.nih.gov/pubmed/24329793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/imr.12131
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