Pulmonary Targeting of Adeno-associated Viral Vectors by Next-generation Sequencing-guided Screening of Random Capsid Displayed Peptide Libraries

Vectors mediating strong, durable, and tissue-specific transgene expression are mandatory for safe and effective gene therapy. In settings requiring systemic vector administration, the availability of suited vectors is extremely limited. Here, we present a strategy to select vectors with true specif...

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Veröffentlicht in:Mol Ther
Hauptverfasser: Körbelin, Jakob, Sieber, Timo, Michelfelder, Stefan, Lunding, Lars, Spies, Elmar, Hunger, Agnes, Alawi, Malik, Rapti, Kleopatra, Indenbirken, Daniela, Müller, Oliver J, Pasqualini, Renata, Arap, Wadih, Kleinschmidt, Jürgen A, Trepel, Martin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4923327/
https://ncbi.nlm.nih.gov/pubmed/27018516
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.62
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