Peptide ligands incorporated into the threefold spike capsid domain to re-direct gene transduction of AAV8 and AAV9 in vivo.

Efficiency and specificity of viral vectors are vital issues in gene therapy. Insertion of peptide ligands into the adeno-associated viral (AAV) capsid at receptor binding sites can re-target AAV2-derived vectors to alternative cell types. Also, the use of serotypes AAV8 and -9 is more efficient tha...

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Main Authors: Stefan Michelfelder, Karl Varadi, Christina Raupp, Agnes Hunger, Jakob Körbelin, Christiane Pahrmann, Sonja Schrepfer, Oliver J Müller, Jürgen A Kleinschmidt, Martin Trepel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2011-01-01
Colecção:PLoS ONE
Acesso em linha:http://europepmc.org/articles/PMC3151269?pdf=render
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