Capsid Serotype and Timing of Injection Determines AAV Transduction in the Neonatal Mice Brain

Adeno-associated virus (AAV) mediated gene expression is a powerful tool for gene therapy and preclinical studies. A comprehensive analysis of CNS cell type tropism, expression levels and biodistribution of different capsid serotypes has not yet been undertaken in neonatal rodents. Our previous stud...

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Detalhes bibliográficos
Main Authors: Chakrabarty, Paramita, Rosario, Awilda, Cruz, Pedro, Siemienski, Zoe, Ceballos-Diaz, Carolina, Crosby, Keith, Jansen, Karen, Borchelt, David R., Kim, Ji-Yoen, Jankowsky, Joanna L., Golde, Todd E., Levites, Yona
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3692458/
https://ncbi.nlm.nih.gov/pubmed/23825679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0067680
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