Microglia-specific targeting by novel capsid-modified AAV6 vectors

Recombinant adeno-associated viruses (rAAV) have been widely used in gene therapy applications for central nervous system diseases. Though rAAV can efficiently target neurons and astrocytes in mouse brains, microglia, the immune cells of the brain, are refractile to rAAV. To identify AAV capsids wit...

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Detalhes bibliográficos
Publicado no:Mol Ther Methods Clin Dev
Main Authors: Rosario, Awilda M, Cruz, Pedro E, Ceballos-Diaz, Carolina, Strickland, Michael R, Siemienski, Zoe, Pardo, Meghan, Schob, Keri-Lyn, Li, Andrew, Aslanidi, George V, Srivastava, Arun, Golde, Todd E, Chakrabarty, Paramita
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4909093/
https://ncbi.nlm.nih.gov/pubmed/27308302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtm.2016.26
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