Widespread and Efficient Transduction of Spinal Cord and Brain Following Neonatal AAV Injection and Potential Disease Modifying Effect in ALS Mice

The architecture of the spinal cord makes efficient delivery of recombinant adeno-associated virus (rAAV) vectors throughout the neuraxis challenging. We describe a paradigm in which small amounts of virus delivered intraspinally to newborn mice result in robust rAAV-mediated transgene expression in...

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Publicat a:Mol Ther
Autors principals: Ayers, Jacob I, Fromholt, Susan, Sinyavskaya, Olga, Siemienski, Zoe, Rosario, Awilda M, Li, Andrew, Crosby, Keith W, Cruz, Pedro E, DiNunno, Nadia M, Janus, Christopher, Ceballos-Diaz, Carolina, Borchelt, David R, Golde, Todd E, Chakrabarty, Paramita, Levites, Yona
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426802/
https://ncbi.nlm.nih.gov/pubmed/25228069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.180
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