Widespread and Efficient Transduction of Spinal Cord and Brain Following Neonatal AAV Injection and Potential Disease Modifying Effect in ALS Mice

The architecture of the spinal cord makes efficient delivery of recombinant adeno-associated virus (rAAV) vectors throughout the neuraxis challenging. We describe a paradigm in which small amounts of virus delivered intraspinally to newborn mice result in robust rAAV-mediated transgene expression in...

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Bibliografiset tiedot
Julkaisussa:Mol Ther
Päätekijät: Ayers, Jacob I, Fromholt, Susan, Sinyavskaya, Olga, Siemienski, Zoe, Rosario, Awilda M, Li, Andrew, Crosby, Keith W, Cruz, Pedro E, DiNunno, Nadia M, Janus, Christopher, Ceballos-Diaz, Carolina, Borchelt, David R, Golde, Todd E, Chakrabarty, Paramita, Levites, Yona
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group 2015
Aiheet:
Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4426802/
https://ncbi.nlm.nih.gov/pubmed/25228069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2014.180
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