Peptide Ligands Incorporated into the Threefold Spike Capsid Domain to Re-Direct Gene Transduction of AAV8 and AAV9 In Vivo

Efficiency and specificity of viral vectors are vital issues in gene therapy. Insertion of peptide ligands into the adeno-associated viral (AAV) capsid at receptor binding sites can re-target AAV2-derived vectors to alternative cell types. Also, the use of serotypes AAV8 and -9 is more efficient tha...

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Detalhes bibliográficos
Main Authors: Michelfelder, Stefan, Varadi, Karl, Raupp, Christina, Hunger, Agnes, Körbelin, Jakob, Pahrmann, Christiane, Schrepfer, Sonja, Müller, Oliver J., Kleinschmidt, Jürgen A., Trepel, Martin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3151269/
https://ncbi.nlm.nih.gov/pubmed/21850255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023101
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