Protein Kinase C-α is a Critical Protein for Antisense Oligonucleotide-mediated Silencing in Mammalian Cells

We have identified the existence of a productive, PKC-α-dependent endocytotic silencing pathway that leads gymnotically-delivered locked nucleic acid (LNA)-gapmer phosphorothioate antisense oligonucleotides (ASOs) into late endosomes. By blocking the maturation of early endosomes to late endosomes,...

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Publicado en:Mol Ther
Autores principales: Castanotto, Daniela, Lin, Min, Kowolik, Claudia, Koch, Troels, Hansen, Bo Rode, Oerum, Henrik, Stein, Cy A
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4923323/
https://ncbi.nlm.nih.gov/pubmed/26961407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.54
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