Stable, Nonviral Expression of Mutated Tumor Neoantigen-specific T-cell Receptors Using the Sleeping Beauty Transposon/Transposase System

Neoantigens unique to each patient's tumor can be recognized by autologous T cells through their T-cell receptor (TCR) but the low frequency and/or terminal differentiation of mutation-specific T cells in tumors can limit their utility as adoptive T-cell therapies. Transfer of TCR genes into yo...

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Publicat a:Mol Ther
Autors principals: Deniger, Drew C, Pasetto, Anna, Tran, Eric, Parkhurst, Maria R, Cohen, Cyrille J, Robbins, Paul F, Cooper, Laurence JN, Rosenberg, Steven A
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2016
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4923320/
https://ncbi.nlm.nih.gov/pubmed/26945006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2016.51
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