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Tumor-infiltrating human CD4(+) regulatory T cells display a distinct TCR repertoire and exhibit tumor and neoantigen reactivity
CD4(+) regulatory T (T(reg)) cells have an essential function in maintaining self-tolerance; however, they may also play a detrimental role in antitumor immune responses. The presence of elevated frequencies of T(reg) cells in tumors correlates with disease progression and poor survival in patients...
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| 發表在: | Sci Immunol |
|---|---|
| Main Authors: | , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2019
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6685542/ https://ncbi.nlm.nih.gov/pubmed/30635355 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aao4310 |
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