Radiotherapy and CTLA-4 blockade shape the TCR repertoire of tumor-infiltrating T cells

Immune checkpoint inhibitors activate T cells to reject tumors. Unique tumor mutations are key T-cell targets, but a comprehensive understanding of the nature of a successful antitumor T-cell response is lacking. To investigate the T-cell receptor (TCR) repertoire associated with treatment success v...

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Publicat a:Cancer Immunol Res
Autors principals: Rudqvist, Nils-Petter, Pilones, Karsten A., Lhuillier, Claire, Wennerberg, Erik, Sidhom, John-William, Emerson, Ryan O., Robins, Harlan S., Schneck, Jonathan, Formenti, Silvia C., Demaria, Sandra
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6020019/
https://ncbi.nlm.nih.gov/pubmed/29180535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-17-0134
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