Efficient nonviral Sleeping Beauty transposon-based TCR gene transfer to peripheral blood lymphocytes confers antigen-specific antitumor reactivity

Genetically engineered lymphocytes hold promise for the treatment of genetic disease, viral infections and cancer. However, current methods for genetic transduction of peripheral blood lymphocytes rely on viral vectors, which are hindered by production and safety-related problems. In this study, we...

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Detalhes bibliográficos
Main Authors: Peng, PD, Cohen, CJ, Yang, S, Hsu, C, Jones, S, Zhao, Y, Zheng, Z, Rosenberg, SA, Morgan, RA
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469249/
https://ncbi.nlm.nih.gov/pubmed/19494842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2009.54
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