Efficient nonviral Sleeping Beauty transposon-based TCR gene transfer to peripheral blood lymphocytes confers antigen-specific antitumor reactivity

Genetically engineered lymphocytes hold promise for the treatment of genetic disease, viral infections and cancer. However, current methods for genetic transduction of peripheral blood lymphocytes rely on viral vectors, which are hindered by production and safety-related problems. In this study, we...

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Hlavní autoři: Peng, PD, Cohen, CJ, Yang, S, Hsu, C, Jones, S, Zhao, Y, Zheng, Z, Rosenberg, SA, Morgan, RA
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3469249/
https://ncbi.nlm.nih.gov/pubmed/19494842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2009.54
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