Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis

Modular collaboration between iterative fungal polyketide synthases (IPKSs) is an important mechanism for generating structural diversity of polyketide natural products. Inter-PKS communication and substrate channeling are controlled in large by the starter unit acyl carrier protein transacylase (SA...

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Bibliographic Details
Published in:J Am Chem Soc
Main Authors: Winter, Jaclyn M., Cascio, Duilio, Dietrich, David, Sato, Michio, Watanabe, Kenji, Sawaya, Michael R., Vederas, John C., Tang, Yi
Format: Artigo
Language:Inglês
Published: 2015
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922798/
https://ncbi.nlm.nih.gov/pubmed/26172141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b04520
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