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Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis

Modular collaboration between iterative fungal polyketide synthases (IPKSs) is an important mechanism for generating structural diversity of polyketide natural products. Inter-PKS communication and substrate channeling are controlled in large by the starter unit acyl carrier protein transacylase (SA...

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Detalhes bibliográficos
Publicado no:J Am Chem Soc
Main Authors: Winter, Jaclyn M., Cascio, Duilio, Dietrich, David, Sato, Michio, Watanabe, Kenji, Sawaya, Michael R., Vederas, John C., Tang, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922798/
https://ncbi.nlm.nih.gov/pubmed/26172141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.5b04520
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