SORLA facilitates insulin receptor signaling in adipocytes and exacerbates obesity

In humans, genetic variation of sortilin-related receptor, L(DLR class) A repeats containing (SORL1), which encodes the intracellular sorting receptor SORLA, is a major genetic risk factor for familial and sporadic forms of Alzheimer’s disease. Recent GWAS analysis has also associated SORL1 with obe...

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Veröffentlicht in:J Clin Invest
Hauptverfasser: Schmidt, Vanessa, Schulz, Nadja, Yan, Xin, Schürmann, Annette, Kempa, Stefan, Kern, Matthias, Blüher, Matthias, Poy, Matthew N., Olivecrona, Gunilla, Willnow, Thomas E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922706/
https://ncbi.nlm.nih.gov/pubmed/27322061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI84708
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