Clinical responses with T lymphocytes targeting malignancy-associated κ light chains

BACKGROUND. Treatment of B cell malignancies with adoptive transfer of T cells with a CD19-specific chimeric antigen receptor (CAR) shows remarkable clinical efficacy. However, long-term persistence of T cells targeting CD19, a pan–B cell marker, also depletes normal B cells and causes severe hypoga...

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Bibliographic Details
Published in:J Clin Invest
Main Authors: Ramos, Carlos A., Savoldo, Barbara, Torrano, Vicky, Ballard, Brandon, Zhang, Huimin, Dakhova, Olga, Liu, Enli, Carrum, George, Kamble, Rammurti T., Gee, Adrian P., Mei, Zhuyong, Wu, Meng-Fen, Liu, Hao, Grilley, Bambi, Rooney, Cliona M., Brenner, Malcolm K., Heslop, Helen E., Dotti, Gianpietro
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2016
Subjects:
Clinical Medicine
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922690/
https://ncbi.nlm.nih.gov/pubmed/27270177
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI86000
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