Gene Expression Profiling Identifies Cell Proliferation and Inflammation as the Predominant Pathways Regulated by Aryl Hydrocarbon Receptor in Primary Human Fetal Lung Cells Exposed to Hyperoxia

Exposure to hyperoxia contributes to the development of bronchopulmonary dysplasia (BPD) in premature infants. We observed that aryl hydrocarbon receptor (AhR) signaling protects newborn mice and primary fetal human pulmonary microvascular endothelial cells (HPMECs) against hyperoxic injury. Additio...

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Detalhes bibliográficos
Publicado no:Toxicol Sci
Main Authors: Shivanna, Binoy, Maity, Suman, Zhang, Shaojie, Patel, Ananddeep, Jiang, Weiwu, Wang, Lihua, Welty, Stephen E., Belmont, John, Coarfa, Cristian, Moorthy, Bhagavatula
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Aryl Hydrocarbon Receptor-Mediated Inflammation and Cell Proliferation in Lung Cells Exposed to High Oxygen
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922543/
https://ncbi.nlm.nih.gov/pubmed/27103661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw071
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