Gene Expression Profiling Identifies Cell Proliferation and Inflammation as the Predominant Pathways Regulated by Aryl Hydrocarbon Receptor in Primary Human Fetal Lung Cells Exposed to Hyperoxia

Exposure to hyperoxia contributes to the development of bronchopulmonary dysplasia (BPD) in premature infants. We observed that aryl hydrocarbon receptor (AhR) signaling protects newborn mice and primary fetal human pulmonary microvascular endothelial cells (HPMECs) against hyperoxic injury. Additio...

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Publié dans:Toxicol Sci
Auteurs principaux: Shivanna, Binoy, Maity, Suman, Zhang, Shaojie, Patel, Ananddeep, Jiang, Weiwu, Wang, Lihua, Welty, Stephen E., Belmont, John, Coarfa, Cristian, Moorthy, Bhagavatula
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2016
Sujets:
Aryl Hydrocarbon Receptor-Mediated Inflammation and Cell Proliferation in Lung Cells Exposed to High Oxygen
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922543/
https://ncbi.nlm.nih.gov/pubmed/27103661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfw071
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