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Photodegradation of retinal bisretinoids in mouse models and implications for macular degeneration
Adducts of retinaldehyde (bisretinoids) form nonenzymatically in photoreceptor cells and accumulate in retinal pigment epithelial (RPE) cells as lipofuscin; these fluorophores are implicated in the pathogenesis of inherited and age-related macular degeneration (AMD). Here we demonstrate that bisreti...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4922174/ https://ncbi.nlm.nih.gov/pubmed/27274068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524774113 |
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