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Iron promotes oxidative cell death caused by bisretinoids of retina

Intracellular Fe plays a key role in redox active energy and electron transfer. We sought to understand how Fe levels impact the retina, given that retinal pigment epithelial (RPE) cells are also challenged by accumulations of vitamin A aldehyde adducts (bisretinoid lipofuscin) that photogenerate re...

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Библиографические подробности
Опубликовано в: :Proc Natl Acad Sci U S A
Главные авторы: Ueda, Keiko, Kim, Hye Jin, Zhao, Jin, Song, Ying, Dunaief, Joshua L., Sparrow, Janet R.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2018
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5948992/
https://ncbi.nlm.nih.gov/pubmed/29686088
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1722601115
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