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Photodegradation of retinal bisretinoids in mouse models and implications for macular degeneration

Adducts of retinaldehyde (bisretinoids) form nonenzymatically in photoreceptor cells and accumulate in retinal pigment epithelial (RPE) cells as lipofuscin; these fluorophores are implicated in the pathogenesis of inherited and age-related macular degeneration (AMD). Here we demonstrate that bisreti...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Ueda, Keiko, Zhao, Jin, Kim, Hye Jin, Sparrow, Janet R.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922174/
https://ncbi.nlm.nih.gov/pubmed/27274068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524774113
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