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Photodegradation of retinal bisretinoids in mouse models and implications for macular degeneration
Adducts of retinaldehyde (bisretinoids) form nonenzymatically in photoreceptor cells and accumulate in retinal pigment epithelial (RPE) cells as lipofuscin; these fluorophores are implicated in the pathogenesis of inherited and age-related macular degeneration (AMD). Here we demonstrate that bisreti...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4922174/ https://ncbi.nlm.nih.gov/pubmed/27274068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524774113 |
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