Blood lipids influence DNA methylation in circulating cells

BACKGROUND: Cells can be primed by external stimuli to obtain a long-term epigenetic memory. We hypothesize that long-term exposure to elevated blood lipids can prime circulating immune cells through changes in DNA methylation, a process that may contribute to the development of atherosclerosis. To...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Dekkers, Koen F., van Iterson, Maarten, Slieker, Roderick C., Moed, Matthijs H., Bonder, Marc Jan, van Galen, Michiel, Mei, Hailiang, Zhernakova, Daria V., van den Berg, Leonard H., Deelen, Joris, van Dongen, Jenny, van Heemst, Diana, Hofman, Albert, Hottenga, Jouke J., van der Kallen, Carla J. H., Schalkwijk, Casper G., Stehouwer, Coen D. A., Tigchelaar, Ettje F., Uitterlinden, André G., Willemsen, Gonneke, Zhernakova, Alexandra, Franke, Lude, ’t Hoen, Peter A. C., Jansen, Rick, van Meurs, Joyce, Boomsma, Dorret I., van Duijn, Cornelia M., van Greevenbroek, Marleen M. J., Veldink, Jan H., Wijmenga, Cisca, van Zwet, Erik W., Slagboom, P. Eline, Jukema, J. Wouter, Heijmans, Bastiaan T.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4922056/
https://ncbi.nlm.nih.gov/pubmed/27350042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-016-1000-6
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